From Charlotte via I-85 South (71 miles, 1.3 hours)

Continue southbound on I-85 past a series of exits marked Spartanburg, including the Business I-85 spur.  Exit #75 (SC-9) is marked "To Wofford College."  At the top of the ramp, 4.3 miles from the campus, turn left.  After the fourth traffic signal, SC-9 turns left down a ramp to join I-585.  Do not turn there, but follow the sign straight ahead to Wofford via North Church Street (US-221). After you pass the Spartanburg Regional Medical Center, be alert to the fact Church Street curves to the left at its intersection with the Asheville Highway.  The front gate to the campus is on the left, 0.4 miles beyond that point.

From Atlanta via I-85 North (170 miles, 3.3 hours)
These directions also apply to campus visitors coming from the Greenville-Spartanburg International Airport. (20 miles, 0.5 hours)

Best Route:  Continue North on I-85 past a series of exits marked Spartanburg, including the Business I-85 Spur.  Exit #72 (US-176/I-585) is marked "To Wofford College."  At the top of the ramp, 4.8 miles from the college, turn right.  Follow the freeway past the USC Spartanburg campus and the Milliken Research Center and take Exit 25-B, North Church Street (US 221).  After you pass the Spartanburg Regional Medical Center, be alert to the fact Church Street curves to the left at its intersection with the Asheville Highway.  The front gate to the campus is on the left, 0.4 miles beyond that point.

Alternate Route:  Leave I-85 at Exit #69, the Spartanburg Business I-85 spur.  Follow the freeway to Exit #4 (Asheville Highway / SC-56), marked "To Wofford College."  At the bottom of the ramp, you are on Hearon Circle.  The second exit off the circle is Asheville Highway and is marked with a Wofford sign.  Continue straight ahead toward downtown Spartanburg for 2.7 miles.  The front gate to the campus is on the left, 0.4 miles after the intersection with North Church Street (US-221).

From Asheville and I-40 via I-26 East (65 miles, 1 hour)

Take Exit #15 (Spartanburg via US-176), marked "To Wofford College."  At the top of the cloverleaf ramp, 8.2 miles from the college, turn right.  After passing the First Baptist Church - North Spartanburg and a shopping center, the highway divides; be sure to bear left and stay on US-176 / I-585.  Follow the freeway past the USC Spartanburg Campus and the Milliken Research Center and take Exit #25-B, North Church Street (US-221).  After you pass the Spartanburg Regional Medical Center, be alert to the fact Church Street curves to the left at its intersection with the Asheville Highway.  The front gate to the campus is on the left, 0.4 miles beyond that point.

From Columbia and I-20 via I-26 West (90 miles, 1.3 hours)

Take Exit #28 (US-221), marked "To Wofford College."  At the bottom of the ramp, 8.9 miles from the college, turn right.  This dual-lane highway, which becomes South Church Street, takes you directly to the Wofford Campus.  After reaching the central business district, continue past the Spartanburg County Library and Morgan Square to the main gate, which is on the right just beyond Spartanburg Memorial Auditorium.